Eukaryotic cells manage to pull off a number of remarkable feats. One is packing quite a long DNA molecule, with potentially billions of base pairs, into a tiny central nucleus. A key role is played by histones, proteins that provide scaffolding for DNA to wrap around. Histones also appear in archaea (one of the other domains of life), but until recently there wasn't evidence for them in bacteria (the final of the three domains). Todays guest, Tobias Warnecke, is an author on a recent paper that claims to provide such evidence. We discuss this new result, as well as background questions of how cells evolved and what their current structure can teach us about their histories.

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Tobias Warnecke received his Ph.D. in biology from the University of Bath. He is currently a Programme Leader and MRC Investigator at the London Institute of Medical Sciences. He is a co-author on A. Hochner et al. (2023), "Histone-Organized Chromatin in Bacteria."

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Here at the Mindscape Podcast, we are firmly pro-reason. But what does that mean, fundamentally and in practice? How did humanity come into the idea of not just doing things, but doing things for reasons? In this episode we talk with cognitive scientist Hugo Mercier about these issues. He is the co-author (with Dan Sperber) of The Enigma of Reason, about how the notion of reason came to be, and more recently author of Not Born Yesterday, about who we trust and what we believe. He argues that our main shortcoming is not being insufficiently skeptical of radical claims, but of being too skeptical of claims that don't fit our views.

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Hugo Mercier received a Ph.D. in cognitive sciences from the École des Hautes Études en Sciences Sociales. He is currently a Permanent CNRS Research Scientist at the Institut Jean Nicod, Paris. Among his awards are the Prime d’excellence from the CNRS.

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If you knew exactly when every person was going to die, or require medical care, you could make a killing buying and selling insurance. Nobody knows these things, of course -- the future is hard to predict -- but some people know something about the future that other people don't. This sets up adverse selection: the ability of one party to leverage information another party doesn't have, in order to gain an economic advantage. Economist Amy Finkelstein is an expert in this phenomenon, as well as the usefulness of empirical studies in economic research.

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Amy Finkelstein received her Ph.D. in economics from the Massachusetts Institute of Technology. She is currently John & Jennie S. MacDonald Professor of Economics at MIT. She is the co-director and research associate of the Public Economics Program at the National Bureau of Economic Research, and the co-Scientific Director of J-PAL North America. Among her awards are a MacArthur Fellowship and the John Bates Clark Medal. Her recent book, with co-authors Liran Einav and Ray Fisman, is Risky Business: Why Insurance Markets Fail and What to Do About It.

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Welcome to the April 2023 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number — based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good — and sometimes group them together if they are about a similar topic. Enjoy!

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Human beings are small compared to the universe, but we're very important to ourselves. Humanism can be thought of as the idea that human beings are themselves the source of meaningfulness and mattering in our lives, rather than those being granted to us by some higher power. In today's episode, Sarah Bakewell discusses the origin and evolution of this dramatic idea. Humanism turns out to be a complex thing; there are religious humanists and atheistic anti-humanists. Her new book is Humanly Possible: 700 Years of Humanist Freethinking, Inquiry, and Hope.

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Sarah Bakewell did postgraduate work in philosophy and artificial intelligence before becoming a full-time author. Among her previous books are How to Live: a life of Montaigne, and At the Existentialist Cafe. She has been awarded the National Book Critics Circle award in biography, as well as the Windham-Campbell Prize in non-fiction.

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Welcome to another episode of Sean Carroll's Mindscape. Today, we're joined by Raphaël Millière, a philosopher and cognitive scientist at Columbia University. We'll be exploring the fascinating topic of how artificial intelligence thinks and processes information. As AI becomes increasingly prevalent in our daily lives, it's important to understand the mechanisms behind its decision-making processes. What are the algorithms and models that underpin AI, and how do they differ from human thought processes? How do machines learn from data, and what are the limitations of this learning? These are just some of the questions we'll be exploring in this episode. Raphaël will be sharing insights from his work in cognitive science, and discussing the latest developments in this rapidly evolving field. So join us as we dive into the mind of artificial intelligence and explore how it thinks.

[The above introduction was artificially generated by gpt.org/">ChatGPT.]

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Raphaël Millière received a DPhil in philosophy from the University of Oxford. He is currently a Presidential Scholar in Society and Neuroscience at the Center for Science and Society, and a Lecturer in the Philosophy Department at Columbia University. He also writes and organizes events aimed at a broader audience, including a recent workshop on The Challenge of Compositionality for Artificial Intelligence.

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Every time our brain does some thinking, there are associated physical processes. In particular, electric currents and charged particles jump between neurons, creating associated electromagnetic fields. These fields can in principle be detected with proper technology, opening the possibility for reading your mind. That technology is currently primitive, but rapidly advancing, and it's not too early to start thinking about legal and ethical consequences when governments and corporations have access to your thoughts. Nita Farahany is a law professor and bioethicist who discusses these issues in her new book, The Battle for Your Brain: Defending the Right to Think Freely in the Age of Neurotechnology.

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Nita Farahany received a J.D. and a Ph.D. in philosophy from Duke University. She is currently the Robinson O. Everett Distinguished Professor of Law & Philosophy at Duke, as well as Founding Director of the Duke Initiative for Science & Society. She has served on a number of government commissions, including the Presidential Commission for the Study of Bioethical Issues. She is a Fellow of the American Law Institute and of the American Association for the Advancement of Science, and was awarded the Duke Law School Distinguished Teaching Award.

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Welcome to the March 2023 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number — based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good — and sometimes group them together if they are about a similar topic. Enjoy!

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God is dead, as Nietzsche’s madman memorably reminded us. So what are we going to do about it? If there is no powerful force out there to guide us and give meaning to our lives, how are we supposed to live? Do we have to come up with meaning and purpose ourselves? Apparently so, and how to pull it off was a major question addressed by the existentialist movement. Skye Cleary turns to Simone de Beauvoir, in particular, for thoughts on how to construct an authentic life. Her recent book is How to Be Authentic: Simone de Beauvoir and the Quest for Fulfillment.

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Skye Cleary received a Ph.D. and an MBA from Macquarie University. She is an author and philosopher and also teaches at Columbia University and the City College of New York. Her writing has appeared in The Paris Review, Aeon, The Times Literary Supplement, TED-Ed, and The Los Angeles Review of Books, among other outlets. She won the 2017 New Philosopher Writers’ Award and was a 2021 MacDowell Fellow. 

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Most of us strive to be good, moral people. When we are doing that striving, what is happening in our brains? Some of our moral inclinations seem pretty automatic and subconscious. Other times we have to sit down and deploy our full cognitive faculties to reason through a tricky moral dilemma. I talk with psychologist Molly Crockett about where our moral intuitions come from, how they can sometimes serve as cover for bad behaviors, and how morality shapes our self-image.

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Molly J. Crockett received her Ph.D. in Experimental Psychology from the University of Cambridge. She is currently Associate Professor of Psychology and University Center for Human Values at Princeton University. She is a Fellow of the Association for Psychological Science and the Society for Experimental Social Psychology.

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