View the Show Notes For This Episode Get Free Weekly Health Tips from Dr. Hyman Sign Up for Dr. Hyman’s Weekly Longevity Journal Get Ad-free Episodes & Dr. Hyman+ Audio Exclusives Dr. Nir Barzilai is a geroscientist, Chaired Professor of Medicine and Genetics, and the founder and principal investigator of the Einstein Nathan Shock Center and the Glenn Center for Excellence in Biology of Aging. He also studies families of centenarians that have provided genetic and biological insights on the protection against aging—with several drugs developed based, in part, on these paradigm-changing studies. He is also leading the TAME (Targeting/Taming Aging with Metformin) trial to prove to the FDA that aging can be delayed and to allow for next-generation interventions.  This episode is brought to you by Sunlighten, Cozy Earth, BiOptimizers, and Fatty 15. For a limited time, you can save up to $600 on a Sunlighten infrared sauna. Just go to sunlighten.com/mark-hyman and mention my name. Right now, you can save 40% when you upgrade to Cozy Earth sheets. Just head over to CozyEarth.com and use code DRHYMAN. Tackle an overlooked root cause of stress with Magnesium Breakthrough. Visit bioptimizers.com/hyman and use code HYMAN10 to save 10% and get a free gift with purchase. Fatty15 contains pure, award-winning C15:0 in a bioavailable form. Get an exclusive 10% off a 90-day starter kit subscription. Just visit Fatty15.com and use code DRHYMAN10 to get started. In this episode we discuss (audio version / Apple Subscriber version): The hallmarks of aging (9:01 / 7:10) What causes the hallmarks of aging? (15:40 / 13:49) Dr. Barzilai’s research on centenarians (23:16 / 21:25) Why living to 100+ years is good for the economy (24:54 / 23:03) What enables someone to live to 100 years old? (29:30 / 25:20) Taking growth hormone and Metformin have different effects based on your age (36:58 / 32:48) The connection between HDL cholesterol and longevity (43:36 / 39:26) Dr. Barzilai’s research on Metformin (56:23 / 52:13) How Metformin works in the body and on muscle growth (1:04:51 / 1:00:41) Dr. Barzilai’s personal longevity (1:42:05 / 1:37:55) Learn more about the Longevity Genes Project and the TAME Trial.  Get a copy of Age Later: Health Span, Life Span, and the New Science of Longevity Learn more about your ad choices. Visit megaphone.fm/adchoices