The Russian journalist and Cambridge-educated historian Vladimir Kara-Murza has been a long-time opponent of President Putin's regime. A dual national who also holds a British passport, he was instrumental in getting the Magnitsky Act passed in now over 30 countries, in a campaign led by financier Bill Browder. The legislation enables governments to sanction Russians engaged in corruption or human rights abuses. He has been a thorn in the side of Putin ever since. More recently he has also spoken out against Russia's war in Ukraine. He was poisoned in Russia, and almost died, twice, in 2015 and 2017, suffering long-term health consequences. Yet he returned to Moscow from the US last year, because he didn’t think he had any right to call people onto the streets into action in Russia if he was sitting safely in America. He was arrested soon after his return, and this week was sentenced to 25 years in a Russian penal colony. But as he wrote from prison: 'the night is darkest before the dawn, but what do you know, the dawn may be just around the corner.' His friends however fear for his life. Presenter Mark Coles speaks to some of those who know him best: Bill Browder, the head of the global Magnitsky Justice Campaign; University of Cambridge historians Dr Clare Jackson and Prof Hubertus Jahn; fellow Russian opposition figure Vladimir Milov, and the BBC's former Moscow correspondent Sarah Rainsford. Producers: Arlene Gregorius and Georgia Coan Sound engineer: Rod Farquhar Editor: Richard Vadon Production Coordinator: Sabine Schereck

Physicist Dr Nicola Fox, who grew up in Hertfordshire, is the new head of science at the US space agency NASA. Only the second woman to hold the post, Dr Fox is a world-renowned expert on the Sun, who'd previously overseen one of the most important missions to study its scientific mysteries. In her new role, Nicola Fox will be responsible for hundreds of NASA projects, including returning humans to the Moon and exploring Mars. Outside of work, she enjoys karaoke... and fashion with a space theme. Mark Coles speaks to Nicola Fox’s friends, family and fellow scientists about how she landed ‘the best job on the planet’. Presenter: Mark Coles Production team: Diane Richardson and Georgia Coan Editor: Simon Watts Sound Engineer: Rod Farquhar

Alvin Bragg, Manhattan's district attorney, is making history and headlines by bringing criminal charges against Donald Trump. It's the first time a former American President has been indicted. The first African-American to hold the office of New York District Attorney, Alvin Bragg is the single child of middle class parents. He was born and brought up in Harlem, although he attended an elite private school on New York's Upper West Side before going to Harvard to study Law. Despite his private education, Bragg was no stranger to the danger on the city's streets in the 1980s; he had guns pointed at him by both the police and a suspected drug dealer. Adrian Goldberg speaks to friends and colleagues of Alvin Bragg about his rise to the job of district attorney in his home town, and how he'll manage the historic case against Donald Trump. Presenter: Adrian Goldberg Production Team: Sally Abrahams, Julie Ball, Georgia Coan Editor: Simon Watts Sound: Neil Churchill Production Co-ordinator: Sabine Schereck

Newly-elected leader of the SNP, Humza Yousaf, has become First Minister of Scotland at the age of just 37. The Glaswegian showed community spirit from a young age, fundraising for charity and broadcasting for community station Radio Ramadan, before a political awakening that led to a speedy rise up the ranks of his party and into office. Humza Yousaf has taken on some difficult government briefs, as well as some flak, but now he faces the challenge of a political lifetime: healing divisions in the SNP, improving public services and trying to deliver the party's dream of independence. Mark Coles talks to friends, family and colleagues to try to find out more about the first ethnic-minority leader of a devolved government. PRODUCTION TEAM Presenter: Mark Coles Production Team: Nathan Gower, Julie Ball, Diane Richardson Editor: Simon Watts Sound: James Beard Production Co-ordinators: Maria Ogundele and Sabine Schereck

Baroness Louise Casey has this week delivered an excoriating review into the standards of behaviour and internal culture of the Metropolitan Police. It’s just the latest of a series of tough reports issued by Casey during a career tackling deep-rooted social issues, including homelessness and anti-social behaviour. Casey is now a cross-bench peer and go-to troubleshooter for governments of all stripes, but her route to the top of public life has been unconventional. Profile speaks to close friends and colleagues of a civil servant known for her fearlessness and no-nonsense style. Presenter: Mark Coles Production team: Sally Abrahams and Nathan Gower Editor: Simon Watts Sound Engineer: Graham Puddifoot

Shadow chancellor and former economist Rachel Reeves, who was a national chess champion aged 14.

Scottish screenwriter Lesley Paterson’s debut film, All Quiet on the Western Front, has won seven BAFTAs and has nine Oscar nominations, including Best Adapted Screenplay. It took her and co-writer Ian Stokell sixteen years to get their script to screen, with Netflix and German director, Edward Berger. On the way, Paterson competed in extreme off-road triathlons, winning five world titles and putting the prize money towards the adaptation rights for the novel. Now the movie is winning awards and provoking debate among critics. Timandra Harkness talks to family, friends and colleagues about Paterson’s childhood going to ballet classes with knees still muddy from rugby, her journey from Stirling to Hollywood, and how her drive to win has got her through every challenge. Presenter: Timandra Harkness Production team: Sally Abrahams, Georgia Coan and Nathan Gower Editor: Simon Watts Sound engineer: Neva Missirian

Born in Jamaica to parents who were both doctors, Professor Dame Angela McLean was fascinated by science from a young age. After studying maths at university, her PhD thesis involved pioneering work on measles. She’s also done ground-breaking research into HIV/AIDS. During the coronavirus pandemic, Dame Angela played a key role drawing up advice for the government. Mark Coles speaks to friends, family and colleagues to find out more about the ‘no-nonsense’, straight-talking scientist who loves theatre, birdwatching and campfires. Presenter: Mark Coles Producers: Sally Abrahams and Georgia Coan Editor: Simon Watts Production Co-ordinator: Sabine Schereck Sound Engineer: Rod Farquhar

Born in London, to Jamaican parents who came to Britain as part of the 1950s Windrush generation, Shirley J. Thompson fell in love with music from a very young age – and it has remained her life’s passion. She’s created music for film, TV, orchestras and opera. Mark Coles talks to family and friends to find out what influences her work. Presenter: Mark Coles Producers: Sally Abrahams and Georgia Coan Editor: Simon Watts Production Co-ordinator: Sabine Schereck Sound Engineer: James Beard

Irish actor Barry Keoghan spent most of his childhood in foster homes, losing his mother to addiction issues when he was just 12-years-old. He found his passion for acting after answering a casting notice for a short indie film in his local shop window. Keoghan was so determined to succeed that he’s often made his own audition tapes to send to studios. Praised by directors for his natural talent, Keoghan has risen from starring in the Irish drama series ‘Love/Hate’ as a ‘cat killer’ in 2013, to the current hit ‘The Banshees of Inisherin’. His moving performance as the comical yet heart-breaking Dominic is wowing critics. So can Barry Keoghan take home all the awards this year? Mark Coles speaks to his friends, colleagues and teachers about his rise from the streets of Summerhill in Dublin to success in Hollywood. Credits Ireland Unfiltered with Dion Fanning In the Envelope: The Actor’s Podcast The Banshees of Inisherin Director and writer: Martin McDonagh Searchlight Pictures Between the Canals Director and writer: Mark O’Connor High Fliers Films Dunkirk Director: Christopher Nolan Warner Bros. Hairspray Director: Adam Shankman Warner Bros. Presenter: Mark Coles Producers: Diane Richardson, Beth Ashmead-Latham and Georgia Coan Editor: Simon Watts Production Co-ordinator: Sabine Schereck Sound Engineer: Rod Farquhar