Dr. Geoff Lecovin shares strategies to improve mental and emotional health with breathing techniques and psychedelics.

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Time Stamps  

05:00 Micro dose of psilocybin is a sub intoxicating dose. Under 500 mg is considered a micro dose. Over 2 grams is a psychedelic experience.

10:00 Holotropic breathwork can lead to an altered state with no entheogens. It can make changes in your brain, upregulating anandamide, dopamine, oxytocin, serotonin, and endorphins.

11:30 Sativa effects the mind and can make you anxious. Indica effects the body in a way that is called the Couch Slouch. They can be combined to bring about the benefits of both.

14:00 Your pH is changed with the blow off of carbon dioxide with breathwork

16:00 Mouth breathing during breathwork brings a more emotional and sympathetic response in continuous breathwork. Nasal breathing increases nitric oxide and prepares the breath for your lungs.

16:50 There are two types of breath holds: one on inspiration and one on expiration. Expiration breath holds bring short term hypoxia, which stimulates healthy chemicals and neurotransmitters. On the inspiration hold, is for connecting with spiritual collective.

20:00 With breathwork you are in a higher suggestible state and more connected state.

21:30 Contraindications for breathwork can be heart problems, uncontrolled high blood pressure, or schizophrenia.

25:52 Breathwork can positively impact HIIT, repair and increases in red blood cells and stem cells. It is anti-inflammatory and anti-ageing.

27:00 Mindset changes your physiology.

27:50 Entheogens are substances that when ingested bring about a non-ordinary state.

29:00 A “threshold dose” of psilocybin is 3 ½ grams.

34:40 During his psychedelic journeys Dr. Lecovin feels gets messages for people.

35:30 The mystical experience of the journey is what helps with the healing.

40:35 Psychedelics do not stimulate the reward centers in your brain, so they are not addictive.

47:15 You don’t lose control when you are experiencing a psychedelic journey. You will come back.

50:30 People who recreationally use mushrooms have significantly lower feelings of anxiety or depression.

53:55 Psychedelics bring neuroplasticity. You feel better the next day.

Evidence suggests diets rich in omega-6 seed oils increase LDL susceptibility to oxidation, which is known to initiate the process of atherosclerosis leading to heart disease.

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Time Stamps: 

0:00 Intro  1:00 Industrial seed oils make your LDL more prone to oxidation. 2:00 Omega 6 linoleic acid is from vegetable oil.  3:20 The half life of linoleic acid in fat tissue is about 2 ½ years. 5:30 There is a link between consuming omega 6 vegetable oils and heart disease. 6:30 Linoleic acid is in higher concentrations in people with coronary artery disease. 6:45 LDL must be oxidized for the development of atherosclerosis. 8:25 Oxidation of LDL is initiated by the oxidation of linoleic acid contained within the LDL particles. 9:25 Oxidized LDL is toxic to endothelial cells of your cardiovascular system and more. 10:20 A diet higher in oleic acid, decrease LDL susceptibility to oxidation. 11:00 Oxidized LDL creates secondary product that that causes damage within the vessels. 11:08 When saturated fat plus trans fat is replaced with omega 6 vegetable oils, there is an increase in all cause mortality and cardiovascular mortality. 13:05 Exposure of the endothelium to linoleic acid is an initial step in the creation of atherosclerosis. 13:30 Consuming more linoleic acid increases the amount of linoleic acid within the aortic plaques.

Emerging data suggests using is ApoB as well as the ApoB/ ApoA1 ratio more accurately assess cardiometabolic disease risk than standard LDL-cholesterol testing. 

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----------------Show Notes-------------------------------

0:00 Intro 0:03 Standard LDL cholesterol measurements are estimates. 0:15 Every atherogenic lipoprotein has one ApoB100. 1:10 ApoB is causally related to atherosclerosis. 2:08 Optimal ApoB is under 60.  4:05 LDL measurements do not correlate to risk. 6:40 Biomarkers of oxidative stress are linked with risk of atherosclerosis. 7:30 Focus on ApoB levels and the ratio or ApoB to apoA1. 8:50 Many people who die of heart disease have low or normal LDL cholesterol. 10:15 Look for biomarker patterns.   11:30 Atherogenic cholesterol is made by your liver. 12:43 Prevent oxidation and do not ingest oxidated seed oils. 15:30 Triglycerides skew LDL measures.

A recently published study finds Berberine might help reverse might atherosclerotic plaque in humans. 

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Time Stamps: 

0:00 Intro 0:05 Berberine has been used in medicine for 3,000 years. 0:23 Berberine treats atherosclerosis. 0:52 Berberine has been shown to regress plaque by 3.8% over 16 weeks. 1:14 Berberine has been used to treat bacterial-caused diarrhea. 1:34 It is a safe and effective treatment for hyperlipidemia treatment and type 2 diabetes. 2:14 Study dose 500 mg 2 times per day. 3:34 A reduction in TMAO was shown in a mouse study. 5:24 Berberine acts on intestinal bacteria. 7:04 Berberine may upregulate LDL receptors on the liver.

Alan Green, MD has been using low-dose rapamycin in his clinical practice for years. We discuss the many potential health benefits and ways this compound can be used as a tool to support healthspan and prevent age-associated diseases. 

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Show Notes: 

05:05 Rapamycin stops this deterioration and the development of dementia. 09:47 Pharmaceuticals do not treat end-stage disease.  11:15 Rapamycin is anti-mTOR. mTOR is involved in all age-related diseases.  19:35 Evolution’s way to promote new gene variations is to eliminate those with old variations with a short lifespan. 24:40 Ageing is a programed genetic timebomb. 30:50 Slowing mTOR with rapamycin slows ageing. 37:40 Transplant patients do not get the age/health benefits because the dosing of rapamycin is too high.  40:18 Once a week dosing gives a high level at the beginning of the week to knock out mTOR1 and it was low enough at the end of the week to not interfere with mTOR2.  41:15 Reducing mTOR1 reduces the activity of the innate immune system.  42:45 Decreasing the innate immune system is good for stopping chronic inflammation and age-related diseases.  48:30 A typical dose is 6 mg. It is less for a smaller healthy person.  50:17 Rapamycin is good for sports performance because it is good for cardiac performance. 54:10 Rapamycin helps maintain strength and quality of muscles.    55:30 Bodybuilders do not benefit from rapamycin. 

Low muscle mass is higher than expected in people recently diagnosed with cancer and cardiovascular disease. Resistance exercise and nutrition may help prevent these chronic diseases.

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References:  

Morlino, D. et al. Prevalence of Sarcopenia in Women with Breast Cancer. Nutrients 14, 1839 (2022).

Jeznach-Steinhagen, A. et al. Higher Muscle Mass and Higher Serum Prealbumin Levels Are Associated with Better Survival in Hemodialysis Patients during a Five-Year Observation Period. Nutrients 15, 1237 (2023).  

Key Takeaways:

00:36 Muscle enhances survivability from chronic disease.

01:10 There was a significant survival benefit from higher quantities of muscle. In chronic kidney disease.

02:00 Resistance training enhances longevity and prevents a variety of disease states.

02:10 Independent of fat mass, survival was higher in those with higher muscle mass.

02:45 Lower muscle mass reflected a worse survival rate in dialysis patients.

03:30 A sudden drop in albumin is an ominous marker, indicating lower survival rates.

07:20 Sarcopenia is found in 14% of breast cancer patients and 1 in 3 had pre-sarcopenia.

08:30 People with low muscle mass have a higher toxicity associated with chemotherapy drugs and have worse outcomes.

10:02 We need to prioritize protein, sleep, recovery, and intense physical activity that involves resistance training.

10:50 Loss of lean mass better predicts a cardiovascular event compared to fat gain.

Dr. Alexis Cowan shares tips about how to improve your gut health and thus metabolic health on a low-carb diet. 

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Show Notes: 

01:50 Your body maintains flux through all metabolic pathways for rapid adaption should the fuel source change.  06:54 Glycerol contributes to glucose production in your liver when you are keto. 07:20 Your neurotransmitters are either made from amino acids or they are amino acids.   09:55 Glutamate can be directly made into GABA.  11:20 Serotonin levels do not correlate with depression. 14:25 Some SSRI’s directly modulate the microbiome.  15:40 Groups of microbes within the gut make lipid amides that interact with peripheral nerves to stimulate the release of dopamine in the area of the brain the encourages movement.  18:45 Human milk oligosaccharides are a potent food source of bifidobacterium.  21:25 Your colon is supposed to be low oxygen.  30:30 During exercise, changes in blood flow can promote the growth of bacteria. 33:12 Regular exercise shifts your immune response to be more anti-inflammatory. 34:45 Carnivore diet, done short term, is beneficial.  39:01 A high fermented food diet is more effective than a high fiber diet.  43:00 Independent scientists in independent labs require crowd or private funding. 46:20 The biggest cause of cavities is dry mouth.  48:30 Using antiseptic mouthwash, can acutely influence exercise performance.  50:00 Ground meat protein is more bioavailable than eating a whole cut of meat.  50:30 There is a connection between antiseptic mouthwash and erectile dysfunction. 

Deaths in children have increased 20% as a result of lockdowns and so called safety measures 'to flatten the curve.

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References:

Woolf SH, Wolf ER, Rivara FP. The New Crisis of Increasing All-Cause Mortality in US Children and Adolescents. JAMA. Published online March 13, 2023. doi:10.1001/jama.2023.3517

Time Stamps:

00:21 There has been a dramatic increase in the death rate of children and adolescents.

01:45 COVID had little to do with the surge in death rates.

02:30 An increase of nearly 20% in all-cause mortality for children ages 1 to 19 years old between has taken place between 2019 and 2022.

03:30 All cause mortality for children 9 and under increased in 2021 by 8.4%.

04:10 Significantly more children died from suicide, homicide, overdoses, and injuries, than died from COVID.

06:45 Injury mortality for ages 10 to 19 rose 22.6% between 2019 and 2020.

06:55 Homicides for ages 10 to 19 rose 39.1% and drug overdose deaths increased by 113.5%.

07:45 Transportation-related deaths increased by 15.6%.

A new study found daily intermittent fasting for ~ 17-19 hours was sufficient to enhance fat loss, metabolic health and bio-markers linked longevity as well as cancer prevention. 

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Time Stamps:  

00:00 Fasting 17 to 19 hours per day for 30 days increased autophagy and increased tumor suppressor P53.

02:10 Autophagy increased, favorable changes were made in the inflammasome hub, and there was a decrease in senescence-associated-signaling molecules.

03:00 P53 helps repair DNA damage, prevents senescence, and contributes to reduced atherogenic risk.

06:05 Autophagy has tissue-specific benefits, especially in the liver and brain.

07:35 Regular exercisers have a great increase in fasted-associated autophagy initiation proteins.

08:35 Long duration fasts can catabolize lean mass, possibly increasing risk for cardiovascular disease.

After years of demonizing dietary cholesterol, the consensus in the medical community is finally shifting: cholesterol-rich foods have a minimal impact on serum LDL or total cholesterol.

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---------------------------Show Notes-----------------------

0:00 Intro 1:10 Insulin regulates the enzyme that synthesizes endogenous cholesterol.  1:50 Dietary cholesterol does not have a significant impact on serum cholesterol.  2:45 Carbohydrates increase LDL and total cholesterol and insulin. 3:30 Cholesterol has powerful benefits.  5:00 Low cholesterol diets can increase endogenous production of cholesterol and the expression of LDL receptors.  5:40 High cholesterol diet expresses fewer LDL receptors.  8:00 Eggs and meat consumption has a minimal impact on serum cholesterol.  8:53 Increased LDL cholesterol may be from of increased fat metabolism. 10:30 Type 2 diabetes and insulin resistance modifies LDL particles to be smaller and denser and more likely to become atherogenic.  13:50 Diabetes can be a side effect of Statin drugs. 14:20 Cholesterol is used to make bile. 16:20 A diet rich in seed oils may foster the modification of LDL cholesterol that can make the atherogenic. 17:45 LDL cholesterol has antiviral properties. 19:30 Insulin resistance and physical inactivity increase triglyceride production, leading to the formation of fats in the liver and elevated triglycerides and elevated vLDL cholesterol.