Tig Notaro dropped out of high school. She drifted between odd jobs for a long time and eventually found her way to Colorado, where she discovered open mic nights and a talent for stand-up comedy.  Stand-up brought discipline to her life. But fame eluded her until 2012, when she released "Live," the comedy album of the stand-up set she performed just four days after she was diagnosed with breast cancer, and soon after her mother suddenly passed away.  Now, Notaro has her own show, "One Mississippi," on Amazon Prime. The show is semi-autobiographical, and she plays a version of herself, a radio host who recently lost her mother and struggles after a double mastectomy.  As we discuss here, "One Mississippi" brilliantly tackles workplace sexual harassment, in terms all too familiar in the wake of the Harvey Weinstein allegations. And it doesn’t stop within the boundaries of the show: Notaro has said that Louis CK, one of her executive producers, needs to “handle” the sexual harassment allegations that have swirled around him. Learn more about your ad choices. Visit podcastchoices.com/adchoices