You can’t do it all, no matter what our crazed culture tells you—and there’s no shame in walking away from a commitment that isn’t working out, as long as you do it thoughtfully, respectfully, and with plenty of advance warning. In the first episode of the LEAP! podcast, Tina Seelig, Professor of the Practice in Stanford’s Department of Management Science & Engineering, and guests Konstantine Buhler of Meritech Capital Partners and John Melas-Kyriazi of Spark Capital embrace the negative, exploring when, why, and how to say no. Life is full of great opportunities, but they’re not all for you.