The "Missing Pieces" of SHIELD are not forgotten by anyone on the team. Daisy and Simmons tirelessly lead a team to find their frozen comrade Fitz, who is out in deep space waiting to rescue them from the future. Unfortunately, they keep hitting dead ends. Back on Earth, Mack has taken over the Directorial responsibilities from Coulson, who has succumbed to his illness and left the mortal world. Mack is a responsible and efficient director that has the respect of everyone. But they are still facing threats and need to build SHIELD back up with new agents and scientists. May tries to recruit Dr. Marcus Benson, who can help in areas of unusual science and also create a new training academy. That is, of course, if they can find a solution to these new reality distortions that are bringing some very surprising visitors to our planet. Jay and Josh return to action as the long hiatus is over on the Season 6 premiere of Agents of S.H.I.E.L.D.: Case Files.