Charles Grodin talks about Movers and Shakers, his many credits,  and Oscar nominations. Kevin Nealon does a stand-up set on Winter, cross-country skiing, filing taxes, and his memories from childhood.

In this episode Johnny jokes about mood rings, Tommy Newsom, the New Hampshire primary, and the LA Rams' recent loss. Carnac uses his divine powers, and no one is safe when Don Rickles shows up. 

Christa and Johnny talk about how she was selected from more than 11,000 applicants to become the first teacher in space. She discusses her plans to teach lessons aboard the Space Shuttle and conduct experiments and demonstrate to the world the wonders of space. Six months after this episode aired, tragically, the Space Shuttle Challenger broke apart upon take off and McAuliffe and her fellow astronauts perished in the disaster. In her honor there are over 40 schools named after Chista. This teacher's true love of space and education truly made her our first civilian astronaut.

Joan Rivers has Johnny and the crowd rolling, as she visits the show on her 25th anniversary of her first appearance on The Tonight Show. 

 Oprah Winfrey’s first appearance on The Tonight Show  with Johnny on February 21st, 1986, when she had just launched The Oprah Winfrey Show and was promoting her new movie, The Color Purple, for which she was nominated for an Academy Award. In this episode, Oprah discusses her talk show success and how she feels comfortable in front of the camera. Also, appearing in this podcast episode is Jerry Seinfeld who talks about Presidents Day, Halloween, and his father's thermostat.

In tonight's monologue, Johnny talks about his attempts to get a date for senior prom. Eddie Murphy is hilarious with his iconic laugh, discussing whether he has a girlfriend, and his first time on the Tonight Show. Following a clip from his latest movie, Beverly Hills Cop, Eddie brings on his friend, Chris Jackson, for an impromptu impression. Ellen Degeneres returns with a funny stand-up set about names and relationships.

Johnny realizes that he and Tommy are wearing similar outfits and reminisces about high school prom. In addition to the recent Emmy Award nominations, Johnny discusses biographies, strikes, and new footage from the Titanic. Actor Charles Grodin discusses his last appearance on The Tonight Show  and asks Johnny more personal questions. Comedian Dom Irerra returns with another hilarious stand-up set about his experience working as a waiter, hating when people smoke in his face, and Judgement Day.

With Halloween coming up, Johnny talks about the rise of realistic latex masks and other frightening things, like the upcoming election. Johnny reads some of the birthday cards he received from fans and welcomes his guests: Orson Welles, Robert Blake, and Dr. Wayne Dyer. Orson Welles talks about his upcoming movies and the forgery of art. Robert Blake discusses show business, being sick, and working in television. Dr. Wayne Dyer goes into detail about his latest book and self-love.

Johnny talks about the recent lawsuit about McDavid's and the government's attempts to curb marijuana use. Tim Conway discusses the recent earthquake and being a television director in Cleveland, and Richard Pryor talks about his parents and being a parent himself, as well as the controversy behind his appearance in California Suite. Meanwhile, Dr. Lendon Smith talks to Johnny, Tim, and Richard about pediatrics, different types of flu, and maintaining a child's health.

In this episode's monologue, Johnny discusses the fruit fly season, Doc Severinsen's outrageous outfit, and the postal service's stamp prices increase. Following Sandra Day O'Connor's recent appointment as the first female Supreme Court Justice, Johnny reads some excerpts from The Behavior Book of 1853. Jerry Seinfeld is back again on The Tonight Show with a hilarious monologue about California, the rise in popularity of mall shopping, and greeting cards.