The vast majority of cannabis enthusiasts and patients are also taking some prescription drug or another, and cannabis patients often ask about the potential for drug-drug interaction without ever getting a satisfying answer. On this episode of Shaping Fire, host Shango Los talks with pharmacologist Jahan Marcu PhD about the complex biology of cannabis interacting with other drugs, how to discern if you may be experiencing an interaction, and some red flag drugs that should be watched closely.

Starting in the 1960s, a single cannabis research group discovered THC, CBD, CBG, CBC, CBNa, CBDa, CBGa and others! On this episode of Shaping Fire, host Shango Los talks with Dr. Ethan Russo about the life’s work of Dr. Raphael Mechoulam, who passed away last week. Dr. Russo shares engaging stories from Dr. Mechoulam’s life, walks us through the historical timeline of his discoveries, and explains the momentous impact of the greatest cannabis researcher we’ve ever known.

The soil food web is at the center of successful cannabis cultivation. On this episode of Shaping Fire, host Shango Los welcomes world-famous soil biologist Dr. Elaine Ingham to discuss using indigenous microorganisms to optimize plant resilience, choosing companion plants by their function, beneficial insects as both garden defense and food web antagonist, using soil food web biomimicry for indoor growing, increasing biological activity in coco coir pots and choosing the right compost tea for the correct use.

The essential nature of living soil is that it is vibrantly alive with a diverse number of species, active fungal systems and is plugged into the larger soil food web. Too often, at the end of the growing season, we simply walk away from our pots, leaving them to the winter elements, or let them dry out in a barn, losing all the biological activity we worked so hard on all summer. On this episode of Shaping Fire, host Shango Los speaks with soil biologist Andie Marsh about the biological reality of off-season pots, living nutrition and infusions than can be used to keep your soil on simmer all winter instead of killing it, and best practices for firing up your soil in the spring.

We are celebrating Shaping Fire episode #100 with a special episode featuring host Shango Los sharing his depth of experience with dosing plans for cannabis patients. Pulling insight and important details from his over decade of experience with cannabis medicine, and interviews he has done with cannabis medicine doctors and researchers, Shango explains a strategic framework of not just cannabis dosing numbers, but rather an entire understanding of how to think through your own ailments and goals so you can figure out your own individualized cannabis medicine needs. Shango shares an incredibly accessible explanation of the Endocannabinoid System, the pros and cons of various consumption methods for patients, explains the mode of action for common cannabinoids as well as specific dosages for a variety of patients, and walks us through the process of planning a personal cannabis protocol where the patient is in control and empowered to make informed decisions based on both science and patient experience.

So many of our efforts as cannabis cultivators are intended to improve the interaction between the plant and soil. And yet, most of us know very little about how plants and microbes really communicate and exchange nutrition and other resources. On this episode of Shaping Fire, host Shango Los talks with plant biologist Sarah Lane about these extraordinary secretions of plants known as exudates, their essential roles in the rhizosphere, challenges with the 24 hour light cycle, exudates in soilless substrate, and the inadequacy of replacing exudates with molasses when feeding microbe life in the soil.

Compost is not one thing. We use compost to describe a whole range of soil amendments. And some of them don’t live up to what we want compost to do. On this week’s episode of Shaping Fire, host Shango Los welcomes back soil biologist Leighton Morrison to talk about the varieties of compost and the benefits and challenges of each, the structure and micro-biology of inoculant organic matter, how to make a microbe-rich cold compost without pathogen risk, and a whole lot of insight into the grading, use and storage of compost.

This episode is for folks who would like to make their first cannabis seeds, and for those simply interested in the process. On this episode of Shaping Fire, host Shango Los talks with Brandon Potter about best practices for making your first seeds, how to choose your parents, effective use of pollen, and harvesting, curing and storing your seeds.

The “Lord of the Roots” returns to Shaping Fire with a fourth book in the essential “Teaming with Microbes” soil food web series. On this episode of Shaping Fire, host Shango Los talks with author and educator Jeff Lowenfels about bacteria’s role in the soil, endophytic bacteria’s rhizophagy cycle ducking into and out of plants themselves, the bacterial life inside cannabis seeds, and how to use these insights in your garden for thriving plants.

Interest in magic mushrooms has skyrocketed and now, for the first time, enthusiasts have access to analytical lab equipment. On this episode of Shaping Fire, host Shango Los talks with biochemist George Sellhorn PhD about performing analyses on psilocybin mushrooms, the key analytes including terpenes labs are presently looking at, the differences between cannabis and psilocybin testing procedures, and how to properly store mushrooms at home to preserve potency.