Have you ever had a wound that took a long time to heal? What if the bandage on your next wound could heal you faster by harnessing the power of your movement? Dr. Zong-Hong Lin and Dr. Snigdha Barman used their bioengineering expertise to create such a system. Their dressing uses embedded piezoelectric devices to convert the body’s motion into electricity, which powers multiple functions designed to overcome specific challenges of wound healing in clinical settings. The dressing, which can be worn continuously for several days, releases hydrogen peroxide to fight bacterial infection while using electrical stimulation to promote healing via cell proliferation, migration, and angiogenesis. We talked with Dr. Lin and Dr. Barman about the motivation for their work, the obstacles they overcame in developing their dressing, and the promises and challenges in its future application. This episode contains musical excerpts from “Drops of God” and “Dark Matter” by Rukudzo Kanyemba.

Vaccines have revolutionized modern medicine, preventing, and even eradicating devastating diseases worldwide. Vaccines leveraging emerging technologies in cellular engineering may lead a revolution in medicine again, starting in brain tumors. In this episode, we hear from Dr. Khalid Shah, a researcher at the forefront of such developments. Dr. Shah and his team are engineering brain tumor cells to create a treatment with direct tumor-killing effects, addressing incomplete tumor margins during excisional surgery. In addition to this direct effect, the treatment also stimulates the immune system to generate long-lasting anti-tumor activity, preventing future recurrence of the same tumor. Music Credits: “Shaolin,” “Inqusitive,” “Fire,” and “Kutapira” by Rukudzo.

When chemist and Nobel Laureate Carolyn Bertozzi was leaving grad school, she asked her professors for letters of recommendation to pursue a postdoc in immunology. They warned her that she was flushing her career down the toilet. Instead, this was one in a series of opportunities that Dr. Bertozzi recognized and pursued, in a career that has changed the way modern chemists work. For this Fireside Chat episode, Dr. Bertozzi told us how she has made a career out of seizing opportunities in the face of pushback, institutional sexism, and the doubts of colleagues. We touched on her experiences finishing grad school without an advisor, building confidence as a young scientist, moving between disciplines, and launching biotech startups. We also talked about the importance of encouragement from friends and colleagues, the inside game of academia, the challenge of keeping a scientifically open mind, and of course what it's like to win a Nobel Prize and invite your dad to Stockholm.

This episode includes musical excerpts from “Nitrogen", "Half Mystery" and "Inspired" by Kevin MacLeod, and "Robots and Aliens" by Joel Cummins.

Social media has infiltrated our society more quickly than any other technological advancement. Kids today have access to endless content and social connections by way of the internet than the generations before them. What effect does a 24/7 connection have on our mental well-being? How does growing up in an age of social media affect our relationships and views of ourselves? In this 360 Perspective episode, we’re exploring the issues surrounding social media and mental health. First, Luisa Fassi tells us about her research on adolescent development and creating a sense of self online. Emma Fyffe opens up about how making a career of her online persona has affected her own mental well-being. Sean Kelley presents his work on algorithms that can identify mental health status from peoples’ language on social media posts. Finally, Dr. Ashley Knapp tells us about the digital tools her team is developing for youth to combat anxiety and how we can make these tools accessible and effective for all.

Music Credits: “The Bounce”, “Samba”, “Afrobeat Instrumental”, “Secret Sauce” and “Lofi for Mental Health” by Rukudzo

Helpful resources:

https://sites.northwestern.edu/ydmhlab/resources/

https://onemindpsyberguide.org/

Varying by country, 5-18% of babies are born pre-term, putting them at risk of medical and developmental complications. While advances in care have greatly improved mortality outcomes for these infants, evidence-based interventions to improve neurodevelopmental outcomes have been more elusive—until now. In this episode, we interview Dr. Martha Welch, a pioneer in pediatric psychiatry, and Dr. Sampsa Vanhatalo, a leading researcher in infant neurophysiology, on their recent work demonstrating how a simple intervention can improve cortical networks and possibly normalize development in this vulnerable population.

Have you ever picked up a video game for the first time and felt completely lost? After a few failed attempts, you surely got better and better each time. In the same way, we can learn how to play a game or use a new piece of technology, scientists at Cortical Labs are teaching brain cells in a Petri dish to play the 1970s arcade classic Pong. With electrical feedback stimulation, the cells can learn to move a virtual platform and volley a ball back and forth with impressive accuracy. In this episode, Dr. Brett Kagan, chief scientific officer at Cortical Labs, tells us how they developed the DishBrain. We discuss how predictable feedback enables neurons to exhibit goal-directed behavior, the question of sentience, and whether we might use synthetic biological intelligence as a medical tool in the future.

As a girl growing up on a remote island farm in western Norway, May-Britt Moser looked at the people and animals around her and wondered what was happening inside them, or in her words, “how the brain is generating behavior, memory, our cognition, our emotions”. Over four decades as a psychologist and neurologist, Dr. Moser has met with astonishing success in answering these questions, leading her team to remarkable discoveries of the neural mechanisms by which we mark time, form memories, and find our way around. In 2014 she was awarded the Nobel Prize in physiology or medicine for discovering the network of so-called grid cells that encode spatial information and enable navigation in humans and other mammals. We talked with Dr. Moser about her research and career; her reflections on science, tenacity, and gender; her analysis of how good science gets done; and (of course) the day she won the Nobel.

The prevalence of Parkinson’s disease has grown more than 50% in recent years, and early onset diagnosis is increasing at an even faster rate. Due to its slow, subtle progression and variable response to medications, this condition can be difficult for clinicians to manage. The work of Dr. Dina Katabi, Director of the MIT Center for Wireless Networks and Mobile Computing, may change that. Her team has shown that discrete, radio wave emitting devices in the home can be used to track patient movement and health parameters like sleep quality. In this episode, Dr. Katabi explains how this work will make healthcare more precise and accessible than ever before. Music Credits: “Land of the midnight sun” and “I hope you hear this” by Rukudzo.

Over 2.8 million people worldwide live with multiple sclerosis (MS), a disease in which the body’s immune system attacks the protective myelin coating around nerves in the brain and spinal cord. People with MS can experience pain, fatigue, memory problems, vision loss, and other debilitating symptoms. MS is relatively rare, but new research has found a causal link between Epstein-Barr Virus, one of the most common human viruses, and MS. In this episode, we talk to Dr. Alberto Ascherio, a Professor of Epidemiology at Harvard School of Public Health, about the 20-year longitudinal databank that reveals Epstein-Barr Virus as a causal factor in MS.

Imagine having a telescope that could allow you to see whether a syndrome will manifest in the future. Imagine being able to use it to cure diseases before they can even occur. For Dr. Thomas McElrath, MD-PhD in the Division of Maternal-Fetal Medicine at the Brigham & Women’s Hospital, this telescope exists and is called LIFECODES. The LIFECODES Biobank is an extensive biobank of samples collected for over 14 years with data on over 6,000 pregnancies. It is used to look at biomarkers associated with pregnancy complications and the effects of environmental exposures on pregnancy outcomes. In this episode, we have interviewed Dr. McElrath to talk about his recent work published in Nature. He has leveraged these data to shed light on normal pregnancy progression to uncover new biomarkers that can be used to diagnose syndromes months before clinical presentation.

 “Zenyatta is my Spirit Animal and Hyacinths’’ music composition administered by Rukudzo © 2022 Rukudzo Kanyemba. All rights reserved.