Introducing Midwest Moxie, a new podcast about the successes, failures, insights and opportunities that shape some of the Midwest’s most exciting entrepreneurs.

On the latest installment of our series on entrepreneurship, How Did You Do That?, host Kathleen Gallagher speaks with Chris Salm about how he went from working at several large food companies to commercializing research out of UW-Madison.

Rock Mackie is a medical physicist who invented a safer type of therapeutic radiation, called tomotherapy, that delivers less radiation with just as much effectiveness. It has saved many lives.

Glen Tullman has an undergraduate degree in economics and psychology, spent a year in Oxford, England studying social anthropology, lived for a year with the Amish, and is a highly successful software entrepreneur. He's founded, grown or invested in more than 20 businesses.

Lori Cross dropped out of her all-girls’ high school in Michigan because there wasn’t enough physics and math to keep her challenged. Technical college was a little better, but Cross found her place at Northwestern University, where she got a degree in chemical engineering and became the first woman to play ice hockey on a men’s NCAA team.

John Splude began his career in public accounting, auditing some of the biggest companies in the area. But he stayed involved with his firm’s smaller clients along with the Fortune 50 companies. And he became more and more interested in the operations side of the businesses.

Robert Jordan spent 20 years as a trucker, driving loads of cheese and other dairy products across the country. Over the miles he educated himself by listening to books on tape and spent hours thinking about how to solve some of the problems he encountered on the road.

Ralph Kauten is a true serial entrepreneur. He co-founded two life sciences companies that sold for a combined $200-plus million and was involved very early in three more. The biggest of those, Promega, has about $450 million of revenue and operations around the world.

Loren Peterson’s path to a successful startup company began on a Nebraska farm. It was a half-mile from the nearest neighbor, 1 mile from where his Swedish ancestors homesteaded, and several miles from the closest town of 600 people. He spent a lot of time hanging out with his two siblings, stacking hay and irrigating cornfields in 100-degree heat, and reading books from the school library and the Bookmobile.

James Phelps thought about starting his own business for a long time. He turned the idea over and over in his mind while: learning about the trades at Milwaukee Tech, working in the Milwaukee Public School district's facilities department, rehabbing houses on the side, getting his undergraduate degree in finance and finishing a commercial real estate certificate program.