Changes are afoot in Downing Street. How significant is the departure of advisor Dominic Cummings? We hear from Conservative MP Michael Fabricant and Sian Jones, who used to be an advisor to former Chancellor Phillip Hammond. A grim milestone has been passed. The number of people who have died with Coronavirus has now exceeded 50,000 in Britain. We speak to a former public health director and author Professor John Ashton and ask him if the early news of vaccines gives us grounds for hope. Other guests include philosopher, cultural commentator and author of 'Learning from the Germans: Race and the Memory of Evil' Susan Neiman, and Director of the Erasmus Forum for Historical and Cultural Research and author of 'Charlemagne, Emperor of the West', and writer and Reader in Early Modern History at Cardiff University, Dr Lloyd Bowen.