Podknife - TWiV 819: How to stall a copy machine by This Week in Virology

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TWiV 819: How to stall a copy machine

Podcast |: This Week in Virology
Publisher |: American Society for Microbiology
Media Type |: audio
Podknife tags |: Health,; Roundtable,; Science & Medicine
Categories Via RSS |: Medicine,; Science & Medicine
Publication Date |: Oct 21, 2021
Episode Duration |: 01:40:32

TWiV explains how remdesivir inhibits the SARS-CoV-2 RNA polymerase: the drug is incorporated into the growing RNA chain and causes synthesis to stall when the drug clashes with an amino acid in the active site.

Hosts: Vincent Racaniello, Alan Dove, Rich Condi t, and Kathy Spindler

Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

How remdesivir stalls the SARS-CoV-2 polymerase (Nat Comm)
Movie of content.springer.com/esm/art%3A10.1038%2Fs41467-020-20542-0/MediaObjects/41467_2020_20542_MOESM4_ESM.mp4"> polymerase stalling (Nat Comm)
Second mechanism of remdesivir inhibition (J Biol Chem)
Watson Crick molecular model (Science Museum Group)
Letters read on TWiV 819
Timestamps by Jolene. Thanks!

Weekly Picks

Kathy – Great Lakes Science Center, Cleveland Rich – How to Temporarily Disable Your Keyboard with a Keyboard Shortcut in Windows Alan – How to Make a Slave and Other Essays by Jerald Walker Vincent – A structure for deoxyribose nucleic acid

Listener Picks

Steve – How the immune system actually works Lise – Lise Meitner: A Life in Physics

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.

Hosts: Vincent Racaniello, Alan Dove, Rich Condi t, and Kathy Spindler

Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

How remdesivir stalls the SARS-CoV-2 polymerase (Nat Comm)
Movie of content.springer.com/esm/art%3A10.1038%2Fs41467-020-20542-0/MediaObjects/41467_2020_20542_MOESM4_ESM.mp4"> polymerase stalling (Nat Comm)
Second mechanism of remdesivir inhibition (J Biol Chem)
Watson Crick molecular model (Science Museum Group)
Letters read on TWiV 819
Timestamps by Jolene. Thanks!

Weekly Picks

Kathy – Great Lakes Science Center, Cleveland Rich – How to Temporarily Disable Your Keyboard with a Keyboard Shortcut in Windows Alan – How to Make a Slave and Other Essays by Jerald Walker Vincent – A structure for deoxyribose nucleic acid

Listener Picks

Steve – How the immune system actually works Lise – Lise Meitner: A Life in Physics

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

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