We discuss the Neuroscience of Pain perception Lukas Krone and Alex von Klemperer talk to Prof Irene Tracey of the Oxford Nuffield Clinical Neurosciences Department about her pioneering work studying chronic and acute pain through neuroimaging as well as some of her more recent projects on Aneasthetic depth. We also discuss how she approaches both being a scientist and taking on executive roles such as head of department and her life outside of science.