Multiple births happen very infrequently. The odds decrease dramatically the more children are born at once. The odds of twins is 1 in 250 pregnancies. The odds of triplets are about 1 in 62,000. The odds of quadruplets are one in 15 million. And the odds of quintuplets, five children, is an astonishing 1 in 55 million. In fact, the first case of natural quintuplets surviving infancy occurred 86 years ago during the Great Depression. Learn more about your ad choices. Visit megaphone.fm/adchoices