Contributor(s): Professor Harlan Krumholz | We find ourselves in the early 21st century with a plethora of data and a paucity of personalised information to transform care and outcomes. With ever more investments in health care, ever more digital data, ever more computational power, we find that our health indices are declining, our disparities increasing, and ability to translate the life science revolution into tangible population health gains diminishing. In what should be the golden age of health, we are caught in neutral at best, and, in some cases, reverse. Our health care infrastructure was built for a different age, and the economic models, poorly suited to current opportunities, resist change that is necessary for progress.