Set primarily in the New Mexico Territory of 1871, the titular Jane is shocked to find her husband, Bill Hammond, riding home after a long time away with bullets in his back. A deadly gang of former outlaw fur traders called "the Bishop Boys", run by the vicious John Bishop have been after them for some time for past betrayals, and Bill informs Jane to get prepared, and perhaps get moving. After dropping off their young daughter with a friend, Jane tries to enlist the services of a former lover named Dan Frost for protection, but they've been separated and estranged since the Civil War drove Jane to have to fend for herself, not knowing if Dan ever made it back from the conflict alive. However, Dan has his own reasons to distrust Jane, and to want Bill out of the picture, causing a tension in loyalties when Dan accepts for a fee, but only because he's trying to get his beloved Jane back.