A seminal 2006 research paper on Alzheimer's has been cited more than 2000 times over the past decade and a half. Its conclusions have informed much of the direction the field has taken since then. And recently an investigation concluded that critical images in the paper may well have been fabricated.

Alzheimer's is already something of a mystery of a disease. We know so little about it. And now it appears we may not even know what we thought we knew. What happened? And what does it mean for so many years of work by so many doctors and scientists?

GUEST: Charles Piller, investigative journalist, Science Magazine

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