Joseph Osmundson, microbiologist, activist, writer, and author of Virology: Essays for the Living, the Dead, and the Small Things in Between (W. W. Norton & Company, 2022) and Jay Varma, physician and epidemiologist, director of the Cornell Center for Pandemic Prevention and Response and professor of Population Health Sciences at Weill Cornell Medicine, share updates on the monkeypox outbreak and the public health response as New York City joins the state in declaring the spread of the virus a public health emergency.