Contributor(s): Winnie Byanyima | This event with Winnie Byanyima, the feminist activist who leads the UN’s response to HIV and AIDS and who chairs the People’s Vaccine Alliance for COVID-19, will highlight lessons rooted in ongoing experience from the AIDS response and the commonalities between the two pandemics, as well as learnings from other health crises, to set out an approach that can actually succeed in keeping us all safe. The COVID-19 crisis has alerted world leaders to the urgency of stopping and preventing pandemics, which are recognised as undermining health, stability, and economic progress. But the path on which the world is embarking to overcome pandemics cannot succeed, because it is failing to address their underlying systemic drivers. Inequalities are increasingly preventing overwhelming majorities in most developing countries from accessing COVID-19 vaccines, enabling the pandemic to spread and the virus to mutate. If we end inequalities upfront, we will increase our odds of ending AIDS, ending COVID-19 and winning against future pandemics. But business as usual will fail. In this time of emergency, the only realistic approach is a radical one, the only safe response is to be bold.