In this Neil Marshall reboot, we already have an established the scarlet-bodied Hellboy (David Harbour) as part of the B.P.R.D. (Bureau of Paranormal Research and Defense), working for his adoptive father, Professor Trevor "Broom" Bruttenholm (Ian McShane), in corraling and eradicating malevolent supernatural menaces wherever they may arise around the world. Hellboy reunites with Alice Monaghan (Sasha Lane), a powerful medium, and a cat-beast man named Major Ben Daimio (Daniel Dae Kim), in order to prevent the Blood Queen from Arthurian times named Nimue (Milla Jovovich) from taking a mate and growing powerful enough to finally take over the world and eliminate the human presence upon it once and for all.