At the beginning of the film, we find the Henry of the title having been all but entirely killed from a brutal attack that sees his eyes, one of his arms, and one of his legs replaced by powerful robotic counterparts from a scientist who tells Henry, who is suffering from severe memory loss, that she is Estelle, his wife. After undergoing the rehabilitative operation, Henry and Estelle find themselves on the run in Moscow from a bunch of Russian gangsters, led by Akan, a madman with astonishing telekinetic powers that are never explained or even commented upon, who is out to create his own team of cyborgs resembling Henry. Estelle ends up getting kidnapped, Henry finds himself under constant assault by a never-ending array of baddies, and the only person who seems to be on his side is a mysterious man who calls himself Jimmy, who seems to have the uncanny ability to regenerate into a new variation of himself whenever he gets killed (Sharlto Copley, in his never-ending quest to see how many dialects he can annoy us hammily performing).