As the U.S. shatters COVID case records, ABC's Chief Anchor George Stephanopoulos goes one-on-one with Dr. Anthony Fauci about the new CDC guidelines for quarantine and isolation, testing availability, and the latest research into the Omicron variant. Plus, with the one year anniversary of the Capitol insurrection approaching, January 6th Committee Chairman Bennie Thompson and Representative Liz Cheney talk about what the committee has learned in its investigation and the state of the Republican Party. And in his first network interview after taking office, New York City Mayor Eric Adams sits down to discuss his strategy to combat the latest COVID surge and his first 100 day priorities for New York City.