Helene Gayle sat down with us to reflect on the expert committee that she and Dr. Bill Foege led recently to map out – in record time – a framework and strategy for the phased introduction of a Covid-19 vaccine in America. For this urgent, complex priority, what are the principles that should guide decisions on who comes first, and who comes later? How best to address gross disparities in the vulnerabilities to Covid-19 of Black, Latinx and Native American populations? What are the essential steps to address widespread distrust and vaccine hesitancy? What comes next, how to navigate the uncertainty and turbulence of these times, and what are the roots of optimism and hope?     Helene Gayle is the President and CEO of the Chicago Community Trust. Previously she was the President and CEO of CARE, and a senior leader at CDC and the Bill and Melinda Gates Foundation. From July through October, she co-chaired with Dr. William Foege the Committee on Equitable Allocation of Vaccine for the Novel Coronavirus, organized by the National Academies of Sciences, Engineering and Medicine. Its final report, ‘Framework for Equitable Allocation of Covid-19 Vaccine,’ was issued October 2, 2020. Helene has been a CSIS Trustee since 2007.