What all the O-line injuries in Carolina are going to do to Cam Newton and that Panthers offense. How are the Patriots going to hold up on Tom Brady's blindside after losing first-round pick Isaiah Wynn? Why the Cowboys are in big trouble if Travis Frederick misses a lot of time. Plus, Adrian Peterson’s impact on Washington’s offense, what Seattle might be doing chasing Jacoby Brissett, and why: No, the helmet-lowering rule is not going to ruin your enjoyment of football this autumn. Got a question for the next mailbag? @GGramling_SI, @Andy_Benoit or talkback@themmqb.com Learn more about your ad choices. Visit megaphone.fm/adchoices