Katie Mox, Will Brinson, and San Francisco 49ers Beat Writer for Niners Nation, Akash Anavarathan. Akash shares some insight on the uncertainties around the 49ers QB situation, what upgrades the defense has made, and what impact Christian McCafrey will have this season.   Hargrave (2:10) QBs (4:23) CMC (11:00) Deebo  (17:21) Join the Pick Six Pro Football Pick'Em Contest: https://picksixpod.football.cbssports.com/opm Get 20% off Pick Six merch using code PICKSIX20: https://store.cbssports.com/collections/pick-six?utm_source=podcast-apple-com&utm_medium=web&utm_campaign=buy-our-merch&utm_content=pick-six-collection Visit the Pick Six YouTube channel: https://www.youtube.com/@NFLonCBS/featured 'Pick Six' is available on Apple Podcasts, Spotify, Stitcher, Google Podcasts, Castbox and wherever else you listen to podcasts. You can listen to Pick Six on your smart speakers! Simply say "Alexa, play the latest episode of the Pick Six NFL podcast" or "Hey Google, play the latest episode of the Pick Six NFL podcast." Follow the Pick Six team on Twitter: @PickSixPod, @KatieMox, @WillBrinson, @ryanwilsonCBS, @johnbreech, @BillTrice31 Check out the Pick Six Instagram page https://www.instagram.com/picksixpod/?hl=en Read the Pick Six newsletter here: https://www.cbssports.com/newsletters/picksix/ Join our Facebook group https://www.facebook.com/groups/758548147935545/ For more NFL coverage from CBS Sports, visit https://www.cbssports.com/nfl/ To hear more from the CBS Sports Podcast Network, visit https://www.cbssports.com/podcasts/ To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices