Podknife - 467: Prion Pivots Productive Pathways by BacterioFiles

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467: Prion Pivots Productive Pathways

Podcast |: BacterioFiles
Publisher |: American Society for Microbiology
Media Type |: audio
Podknife tags |: Natural Sciences,; Science & Medicine
Categories Via RSS |: Life Sciences,; Science
Publication Date |: Dec 27, 2021
Episode Duration |: 00:13:53

This episode: Prions in yeast can allow better adaptation to changing conditions!

Download Episode (9.5 MB, 13.9 minutes) Show notes: Microbe of the episode: Hepatovirus F

News item

Takeaways

Prions can be deadly. They're misshapen proteins that cause a cascade of misfolding of similar proteins if they get into the nervous system, resulting in neurodegeneration in mammals. But in other organisms, they are not always so scary; some fungi use prions to regulate their behavior in varying conditions.

In this study, a prion allows yeast to switch between a fast-growing lifestyle with shorter reproductive lifespan that can be beneficial in conditions where nutrients are often plentiful, and a slower-growing but more enduring lifestyle that helps in more scarce conditions.

Journal Paper: Garcia DM, Campbell EA, Jakobson CM, Tsuchiya M, Shaw EA, DiNardo AL, Kaeberlein M, Jarosz DF. 2021. A prion accelerates proliferation at the expense of lifespan. eLife 10:e60917.